铔嬬櫧閰堕珨鎶戝埗鍔�(proteasome inhibitor)閫氶亷鎶戝埗铔嬬櫧閰堕珨鐨勬椿鎬�锛�閫茶�屽奖闊跨窗鑳炵敓闀风浉闂�(gu膩n)铔嬬櫧銆�绱拌優鍥犲瓙鍜屼俊铏熷垎瀛愮殑琛ㄩ仈锛� 骞叉摼绱拌優鍘熸湁鐨勫娈�銆�鍒嗗寲鍜屽噵浜￠亷绋�銆�铔嬬櫧閰堕珨鎶戝埗鍔戜綔鐢ㄤ簬姝ｅ父绱拌優甯告渻寮曡捣绱拌優鍛ㄦ湡闃绘化锛�鑰屼綔鐢ㄤ簬鑵槫绱拌優鍓囨洿瀹规槗鐧�(f膩)鐢熺窗鑳炲噵浜�[1]銆�楂斿収(n猫i)澶栬│椹楀凡椤ず铔嬬櫧閰堕珨鎶戝埗鍔戝叿鏈夊唬娉涙姉鑵槫浣滅敤銆�鐧鹃潏濞佷緵鎳夐珮绱斿害铔嬬櫧閰堕珨鎶戝埗鍔�锛�璩�(zh矛)鎺у毚鏍�锛�璨ㄦ湡绌�(w臎n)瀹�锛�淇冮��瀵﹂鐨勯爢鍒╅�插睍[2]銆�鍚屾檪锛�鐧鹃潏濞佷綔鐐哄皥妤�(y猫)瑭﹀姂渚涙噳鍟�锛�鐐鸿棩鐞嗚垏钘ヤ唬鐮旂┒闋�(l菒ng)鍩熷鎴舵彁渚涜叓鐦ょ爺绌跺寲鍚堢墿绯诲垪銆�閰舵姂鍒跺姂鍜屾縺娲诲姂绯诲垪銆�鍙楅珨鎷姉鍔戝拰婵�娲诲姂绯诲垪銆�鐤�鐥呮ā鍨嬪埗鍌欒│鍔戠郴鍒楃瓑400浣欑ó鐢�(ch菐n)鍝�銆�
- 浣滅敤闈堕粸娓呮櫚锛�鏂逛究鎮ㄧ殑閬告搰
- 澶氱ó鍖呰瑕�(gu墨)鏍�锛�绱拌優鎴栧嫊鐗╁椹楀潎鑳芥豢瓒抽噺绱氶渶姹�
- 鍦嬪収(n猫i)鐝�(xi脿n)璨�锛�蹇�熺櫦(f膩)璨�
鍦�1 MG132灏峈aji绱拌優褰㈡厠(t脿i)鐨勫奖闊�[3]
鍦�2 娴佸紡绱拌優琛�(sh霉)妾㈡脯MG132灏峈aji绱拌優鍑嬩骸鐨勫奖闊�[3]
鍦�3锛�SAHA鑱�(li谩n)鍚�MG132鍙鍔�K;562绱拌優鍏�(n猫i)ROS鐨勭敘(ch菐n)鐢�[4]
References:
[1] Yang Y,Kitagaki J,Dai RM,et al. Cancer Research . 2007
[2] Garcia-Manero G,Yang H, Bueso-Ramos C,Ferrajoli A,Cortes J, Wierda. Blood. 2008 Febl;lll(3):1060-6.
[3] 鍔夊媷,榫嶆嵎,鑾ゥ铇�,铇囩铇�,閭垫槬濂�,璎濇泬鏂�. 铔嬬櫧閰堕珨鎶戝埗鍔慚G132灏峈aji绱拌優鍑嬩骸銆佺窗鑳炲懆鏈熷強UBE1鍩哄洜琛ㄩ仈鐨勫奖闊�. [J].涓北澶у瀛稿牨. 2011(03)
[4] 鑲栧嘲. SAHA鑱�(li谩n)鍚圡G132灏嶆參鎬ч珦绱拌優鐧借鐥呯窗鑳炴牚鐨勬鍌峰強鑱�(li谩n)鍚堜綔鐢ㄦ鍒剁殑鐮旂┒[D]. 娴欐睙澶у.2015
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鐢�(ch菐n)鍝佺法铏�
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鐢�(ch菐n)鍝佸悕绋�
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CAS
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鍙冭�冪敤閫�
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1386067
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A 769662, 98%
4-缇ュ熀-3-(2'-缇ュ熀-1,1'-鑱�(li谩n)鑻�-4-鍩�)-6-姘т唬-6,7-浜屾矮鍣诲惄骞�[2,3-B]鍚″暥-5-鐢茶厛, 98%
|
844499-71-4
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AMPK婵�娲诲姂
|
|
996037
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Afatinib, 98%
闃挎硶鏇垮凹, 98%
|
850140-72-6
|
EGFR鎶戝埗鍔�
|
|
588527
|
Diclofenac sodium, 98%
闆欐隘鑺吀閳�, 98%
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15307-79-6
|
闈為伕鎿囨��COX鎶戝埗鍔�
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|
113424
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Doxorubicin hydrochloride, 98%
楣介吀闃块湁绱�, 98%
|
25316-40-9
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DNA topoisomerase II鎶戝埗鍔�
|
|
341249
|
Erlotinib, 98%
鍩冪緟鏇垮凹, 98%
|
183321-74-6
|
EGFR鎶戝埗鍔�
|
|
114089
|
7-Ethyl-10-hydroxycamptothecin, 99%
7-涔欏熀-10-缇ュ熀鍠滄ü鍫�, 99%
|
86639-52-3
|
DNA topoisomerase I鎶戝埗鍔�
|
|
916054
|
Flurbiprofen, 99%
姘熸瘮娲涜姮, 99%
|
5104-49-4
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闈炵斁楂旀姉鐐庡寲鍚堢墿
|
|
960385
|
Hydrocortisone, 98%
姘寲鍙殑鏉�, 98%
|
50-23-7
|
绯栫毊璩�(zh矛)婵�绱犲彈楂旀縺鍕曞姂
|
|
257998
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Metformin hydrochloride, 98%
浜岀敳闆欒儘楣介吀楣�, 98%
|
1115-70-4
|
AMPK 婵�娲诲姂
|
|
922806
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Naproxen, 98%
钀樻櫘鐢�, 98%
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22204-53-1
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COX鎶戝埗鍔�
|
|
176239
|
SB 203580, 98%
4-(4-姘熻嫰鍩�)-2-(4-鐢插熀浜炵：?锛涱姠浜�?/span>)-5-(4-鍚″暥鍩�)-1H-鍜攽, 98%
|
152121-47-6
|
p38 MAPK鎶戝埗鍔�
|
|
1430418
|
Tofacitinib citrate, 99%
妾告閰告墭娉曟浛灏�, 99%
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540737-29-9
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JAK3鎶戝埗鍔�
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|
628151
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Vorinostat, 99%, SAHA
浼忕珛璜句粬, 99%, SAHA
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149647-78-9
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HDAC鎶戝埗鍔�
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鐩搁棞(gu膩n)瑭﹀姂锛�