生物電子等排原理是將化合物結(jié)�(gòu)中的某些原子或基�(tuán),用其外層電子總�(shù)相同或(等價(jià))或者化�(xué)反應(yīng)性和氫鍵形成能力等重要參�(shù)相似性的原子或基�(tuán)�(jìn)行替�,從而產(chǎn)生的新化合物�
立方烷是苯環(huán)的生物電子等排體而應(yīng)用于藥物研發(fā)。其非平面結(jié)�(gòu)性可以使藥物的溶解性增�� 并且立方烷穩(wěn)定的sp3 C-H鍵可以使藥物在代謝中具有更好的穩(wěn)定性。已有研究顯示一些醫(yī)藥化合物的苯�(huán)立方烷衍生物藥理活性更�[1]。百靈威作為專業(yè)試劑供應(yīng)�� 提供一系列新型苯環(huán)生物電子等排體,可用于新藥研�(fā)生產(chǎn)�
�(chǎn)品編�(hào)
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�(chǎn)品名�
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CAS
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�(jié)�(gòu)�
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包裝
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2063671
|
Cubanecarboxylic acid, 98%
立方烷甲�, 98%
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53578-15-7
|
|
100 mg
250 mg
1 g
|
106255
|
1,4-Cubanedicarboxylic acid, 97%
1,4-立方烷二羧酸, 97%
|
32846-66-5
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.PNG)
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250 mg
1 g
5 g
|
511525
|
Dimethyl 1,4-cubanedicarboxylate, 95%
1,4-立方烷二甲酸二甲�, 95%
|
29412-62-2
|
|
250 mg
1 g
5 g
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484520
|
4-Methoxycarbonylcubanecarboxylic acid, 97%
4-甲氧羰基立方烷羧�, 97%
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24539-28-4
|
.PNG)
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250 mg
1 g
5 g
|
� 1:Benzene-ring-containing pharmaceutical and agrochemical compounds and the corresponding cubane analogues with hypothetical trade names.
References
[1] Chalmers B A, Xing H, Houston S, et al. Validating Eaton's Hypothesis: Cubane as a Benzene Bioisostere[J]. Angewandte Chemie International Edition, 2016. 3580-3585.
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�(chǎn)品編�(hào)
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名稱
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CAS
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�(jié)�(gòu)�
|
包裝
|
167279
|
Benzyl benzoate, 99%
苯甲酸芐�, 99%
|
120-51-4
|
.PNG) |
50 mL
250 mL
1 L
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117147
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4-Dimethylaminopyridine, 99%
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1122-58-3
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5 g
25 g
100 g
500 g
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130992
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Diphenylphosphoryl azide, 98%
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26386-88-9
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5 g
25 g
100 g
|
251734
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94-09-7
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25 g
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