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鐧鹃潏濞佸皥妤�(y猫)鎻愪緵Echelon鍝佺墝PI3K绯诲垪鐢�(ch菐n)鍝�銆侲chelon鏄編鍦嬭憲鍚嶇殑鐢熷寲鐢�(ch菐n)鍝佷緵鎳�(y墨ng)鍟�锛屽皥娉ㄤ簬鑴傞锛圠ipid锛夌爺绌堕牁(l菒ng)鍩�锛岀偤寤ｅぇ鏂拌棩鐮旂櫦(f膩)銆佺硸灏跨梾鍙婄檶鐧ョ瓑鐤剧梾瑷烘柗绉戠爺宸ヤ綔鑰呮彁渚涙渶鍏堥��(j矛n)鐨勭爺绌跺伐鍏�銆�
PI3-K瀹舵棌鍙冭垏澶氱ó淇¤櫉(h脿o)閫氳矾锛屽彲瑾�(di脿o)绡�(ji茅)绱�(x矛)鑳炵殑涓昏鍔熻兘銆傛甯告儏娉佷笅锛岀敱鍏舵椿鍖栬�岀敘(ch菐n)鐢熺殑椤炶剛鐢�(ch菐n)鐗PI(3,4)P2]鍜孾PI(3,4,5)P3]浣滅偤绗簩淇′娇绲�(ji茅)鍚堝苟婵�娲诲绋窗(x矛)鑳炲収(n猫i)鐨勯澏铔嬬櫧锛屽舰鎴愪竴鍊�(g猫)淇¤櫉(h脿o)绱�(j铆)鑱�(li谩n)寰�(f霉)鍚堢墿锛屾渶绲傝(di脿o)绡�(ji茅)绱�(x矛)鑳炵殑澧炴畺銆佸垎鍖�銆佸瓨娲诲拰閬风Щ绛�銆�
Class鈪燩I3-K鏄竴鍊�(g猫)浜岃仛楂旇泲鐧�锛屽叿鏈夐鑴傛縺閰跺拰铔嬬櫧婵�閰剁殑闆欓噸娲绘�с�傛縺娲诲悗鐨凱I3-K鑳藉湪璩�(zh矛)鑶滀笂浣縖PI(3,4)P2]纾烽吀鍖栨垚[PI(3,4,5)P3]锛� [PI(3,4,5)P3]鍙皫(d菐o)鑷碅kt鐨勬椿鍖�?锛涚建顕厑kt閫氶亷纾烽吀鍖栦綔鐢ㄦ縺娲绘垨鎶戝埗鍏朵笅娓哥殑Bad銆丆aspase9銆丯F-kB銆丟SK-3銆丗KHR銆乸21銆乸27绛夐澏铔嬬櫧锛岄��(j矛n)鑰岃(di脿o)绡�(ji茅)绱�(x矛)鑳炵殑澧炴畺銆佸垎鍖�銆佸噵浜′互鍙婇伔绉�銆傚洜鑰孭I3-K鍜孾PI(3,4,5)P3]宸茬稉(j墨ng)鎴愮偤灏�(du矛)鍖呮嫭鐐庣櫏銆佺檶鐧ョ瓑澶氱ó鐤剧梾閫�(j矛n)琛岀爺绌跺拰钘ョ墿瑷�(sh猫)瑷�(j矛)鐨勯澏鐩镐綅榛�(di菐n)銆�
Echelon鐐篜I3K鐮旂┒鑰呮彁渚涘緸PI3-Kinase銆佸簳鐗┿�佹縺閰舵姂鍒跺姂銆佹姉楂斿埌婵�閰舵椿鎬ф娓│鍔戠洅鐨勫叏濂楄В姹烘柟妗�锛涘悓鏅�(sh铆)閲囩敤绔剁埈鎬ф娓墜娈�锛岄潪鏀惧皠鎬ф娓�锛屾瘮鍌崇当(t菕ng)鏂规硶鏇村姞瀹夊叏銆佷究鎹枫�侀珮鏁�锛�
PI3-K鐩搁棞(gu膩n)鐢�(ch菐n)鍝�
1銆� Inhibitors——PI 3-Kinase Inhibitors锛堟姂鍒跺姂锛�
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AS604850 (PI3-K gamma Inhibitor 2)
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AS605240 (PI3-K gamma Inhibitor 1)
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LY294002 (PI3-K Inhibitor)
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PI-103 (PI3-K alpha Inhibitor 1)
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PI3-K alpha Inhibitor 2
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Resveratrol
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Wortmannin
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2銆丄ssay Service锛堝垎鏋愭湇鍕�(w霉)锛�
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PI3-Ka Inhibitor Screening Service
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PI3-Kb Inhibitor Screening Service
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3銆丄ssays——PI3-Kinase Assay锛圥I3-K妾㈡脯锛�
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5X KBZ Buffer
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AS604850 (PI3-K gamma Inhibitor 2)
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AS605240 (PI3-K gamma Inhibitor 1)
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Class III PI3-K ELISA Kit
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LY294002 (PI3-K Inhibitor)
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K-31PC
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Phosphatidylcholine Assay Kit
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K-3100
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Phosphatidylcholine Sphingomyelin Assay Kit
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PI 3-Kinase Fluorescence Polarization Kit, 384 assays
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PI-103 (PI3-K alpha Inhibitor 1)
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PI3-K alpha Inhibitor 2
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PI3-K AlphaScreen®
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K-1000
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PI3-K ELISA Kit
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K-2600
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PI3-Kinase 384 well ELISA
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PI3-Kinase ELISA: Pico Assay
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G-1200
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PIP3 Grip
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K-31SM
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Sphingomyelin Assay Kit
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Transcreen ADP2 FI Assay - 384 well
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Transcreen ADP2 FI Assay - 96 well
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K-2700s
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TRueFRET PI3-K Activity Assay
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K-2700
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TRueFRET PI3-Kinase TR-FRET assay
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4銆丩ipid Kinase锛圥I3-K婵�閰讹級
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E-K084G
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Ceramide Kinase, active
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PI3 kinase alpha, active
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PI3K (p110alpha/p85alpha), active
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PI3K (p110beta/p85alpha), active
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PI3Ka, E545K - Active Mutant
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5銆丳I3-K鎶楅珨
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Anti-hVps34 Antibody for IP
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Anti-hVps34 Antibody for WB
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