鈻� 鐢㈠搧浠嬬垂
纭肩兎瑭﹀姂鏄湁姗熷寲瀛稿悎鎴愪腑闈炲父閲嶈鐨勪竴椤炶│鍔戯紝閫氶亷纭艰│鍔戠殑鍙冭垏锛屽彲瀵︾従(xi脿n)鐗瑰畾妲嬪瀷鎵嬫�у寲鍚堢墿鐨勫悎鎴�锛屾槸鐛插緱楂樺厜瀛哥磾搴﹀寲鍚堢墿鐨勪竴绋噸瑕侀�斿緫銆�
纭肩兎椤炶│鍔戝湪鍙嶆噳涓叿鏈夎純寮风殑绔嬮珨閬告搰鎬у拰杓冮珮鐨勫弽鎳夋敹鐜�锛屽叾鍙冭垏鐨勭珛楂旈伕鎿囨�ч倓鍘熷弽鎳夊凡琚唬娉涙噳鐢ㄤ簬鎵嬫�ц棩鐗╁強鍏朵腑闁撻珨鐨勫悎鎴愪腑銆傚鐩墠鍏ㄧ悆骞撮姺鍞閬旀暩(sh霉)鍗佸剟缇庡厓鐨勪粬姹�椤為檷琛�鑴傝棩鐗┿�侀�氶亷闃绘柗鑶藉浐閱囪吀鍚告敹鐨勯檷琛�鑴傝棩渚濇浛绫宠矟(Ezetimibe)銆� 鍖栫檪姝㈠悙钘ラ樋鐟炲尮鍧�(Aprepitant)銆佸叿鏈夋姉鑿屽拰鎶楄叓鐦や綔鐢ㄧ殑鐢鹃珨椤炲寲鍚堢墿瑙掗瘖澶氳兒(Squalamine)銆佷互鍙婁綔鐢ㄤ簬绱拌優寰鐨勬柊鍨嬫姉鑵槫钘ョ墿鍩冨潯闇夌礌(Epothilone)绛夌瓑銆�
鐧鹃潏濞佸彲鎻愪緵骞惧崄绋〖鐑疯│鍔�锛屾湁鏁堢〖鐑峰惈閲忛珮锛屾壒娆¤唱閲忕┅(w臎n)瀹�锛屽彲鎻愪緵澶氱ó鍖呰瑕�(gu墨)鏍硷紝绲︽偍鐨勮│椹楀強鐢熺敘鏇村閬告搰锛屽姪鍔涢啱(y墨)钘ョ爺鐧�(f膩)浜嬫キ(y猫)锛�
鈻� 纭肩兎瑭﹀姂
|
鐢㈠搧绶ㄨ櫉
|
鐢㈠搧鍚嶇ū
|
绲愭寮�
|
CAS
|
|
266741
|
纭肩兎浜岀敳纭啔
Borane dimethyl sulfide complex, 2M in THF
|
 |
|
|
964720
|
纭肩兎浜岀敳纭啔
Borane dimethyl sulfide complex, 10M in DMS
|
|
|
|
280157
|
纭肩兎鍥涙矮鍛嬪杻
Borane-tetrahydrofuran complex, 1M in THF, stabilized with 0.005M NaBH4
|
 |
|
|
223656
|
纭肩兎-N,N-浜屼箼鍩鸿嫰鑳虹怠鍚堢墿
Borane-N,N-diethylaniline complex, 96%
|
 |
|
|
512634
|
9-纭奸洐鐠�(hu谩n)[3.3.1]澹兎
9-Borabicyclo[3.3.1]nonane, 0.5M in THF
|
|
|
|
611975
|
纭肩兎鍡庡晧绲″悎鐗�
borane morpholine complex, 97%
|
|
|
|
953607
|
闋婚偅閱囩〖鐑�
Pinacolborane, 97%
|
|
|
|
610284
|
鍏掕尪閰氱〖鐑�
Catecholborane, 1M in THF
|
|
|
|
116849
|
涓夛紙浜旀盁鑻級纭�
Tris(pentafluorophenyl)borane, 94%
|
|
|
|
345201
|
涓変箼鍩虹〖
Triethylborane, 1M in THF
|
|
|
|
296463
|
涓変箼閰版哀鍩虹〖姘寲閳�
Sodium triacetoxyborohydride, 97%
|
|
|
|
509190
|
涓変箼鍩虹〖姘寲閶�
Lithium triethylborohydride, 1M in THF
|
|
|
|
314162
|
姘板熀纭兼矮鍖栭垑
Sodium cyanoborohydride, 95%
|
NaBH3CN
|
|
Ref.
[1] Song, H. Y.; Joo, J. M.; Kang, J. W.; Kim, D.; Jung, C.;Kwak, H. S.; Park, J. H.; Lee, E.; Hong, C. Y.; Jeong, S.W.; Jeon, K.; Park, J. H. J. Org. Chem. 2003, 68, 8080.
[2] Xian xu, Renzhong fu, Jin Chen. Ezetimibe analogs with a reorganized azetidinone ring: Design, synthesis, and evaluation of cholesterol absorption inhibitions [J].Bio org med Chem. 2007, (17):101-104.
鈻� 閰嶅鐢㈠搧鎺ㄨ枽
|
|
鐢㈠搧绶ㄨ櫉
|
鐢㈠搧鍚嶇ū
|
CAS
|
|
鏍兼皬瑭﹀姂
|
917218
|
鐢插熀婧村寲閹�
Methylmagnesium bromide, 3 M in diethyl ether
|
|
|
248474
|
涔欏熀婧村寲閹�
Ethylmagnesium bromide, 1.0 M solution in THF
|
|
|
309166
|
涔欑儻鍩烘捍鍖栭巶,
Vinylmagnesium bromide, 1.0 M solution in THF
|
|
|
356369
|
鐑笝鍩烘隘鍖栭巶
Allylmagnesium chloride, 2.0 M solution in THF
|
|
|
閶伴瑭﹀姂
|
274232
|
姝ｄ竵鍩洪嫲
n-Butyllithium, 1.6 M solution in hexanes
|
|
|
913796
|
姝ｄ竵鍩洪嫲
n-Butyllithium, 2.4 M solution in hexanes
|
|
|
閲戝爆鍌寲鍔�
|
182482
|
鍥�( 涓夎嫰鍩鸿啨) 閳�(0)
Tetrakis(triphenylphosphine)palladium(0), 99.8%
|
|
|
|
[1,1'-闆�(浜岃嫰鍩鸿啨)浜岃寕閻�]浜屾隘鍖栭垁
1,1'-Bis(diphenylphosphino)ferrocene palladium dichloride, 99%
|
|
|
|
閱嬮吀閳�(鈪�)
Palladium(鈪�) acetate, 47.5% Pd
|
|
J&KSeal 鐒℃按鐒℃哀鍖呰
J&KSeal 楂樺搧璩劇姘寸劇姘у寘瑁濆叿鏈夊壍(chu脿ng)鏂扮殑铻虹磱瀵嗗皝钃嬭ō瑷�銆佷竷瀛旀娊鍙栭潰瑷▓鍙婇洐灞ら殧鑶滅摱澧�瑷▓锛屽彲鏈�澶х▼搴︿繚璀夌敘鍝佺殑鍝佽唱锛屽皪绌烘埃鍜屾按鍒嗘晱鎰熼瑭﹀姂鐢㈠搧锛屽鏍兼皬瑭﹀姂銆侀嫲椤炶│鍔�銆佽秴骞叉憾鍔戠瓑锛岀櫨闈堝▉鍧囬噰鐢�J&Keal 灏堟キ(y猫)鐒℃按鐒℃哀鍖呰锛岃垏甯傚牬涓婄殑鍏跺畠鍖呰鐩告瘮锛孞&KSeal 楂樺搧璩劇姘寸劇姘у寘瑁濊〃鐝�(xi脿n)鍑烘渶鍎�(y艒u)鐣扮殑鎬ц兘锛�
鈽� 榛冭壊瀹夊叏鎵嬫墸——纰轰繚鐢㈠搧鏈闁嬪暉锛�
鈽� 瀵嗗皝铻虹磱绲愭瑷▓——钃嬭垏鐡惰韩澶氶噸铻虹磱瀵嗗悎锛屾渶澶х▼搴︿繚璀夊瘑灏佹��锛�
鈽� 鐛ㄧ壒鐨勪竷瀛旀娊鍙栭潰——閬垮厤鍚屼竴鍦版柟澶氭绌垮埡锛屾笡灏忚畩褰㈠嵄闅��锛屽苟鍙洿濂界殑鍐嶆瀵嗗皝鎬�锛�
鈽� 闆欏堡闅旇啘鐡跺——PTFE鑸囩妯硅剛鏉愯唱鍒舵垚锛屽帤搴︽槸鍏跺畠鍚岄鍖呰鐨勫叐鍊�锛屾敞灏勫櫒閲濋牠绌垮埡鎳夊姏姣斿叾瀹冨悓椤炲寘瑁濆皬40%锛屾渶澶х▼搴﹂檷浣庣┛鍒哄彇妯ｆ檪鐧�(f膩)鐢熸剰澶栧咕鐜�锛�
鈽� 娉ㄥ皠鍣ㄥ強鎿拌搵鍏╃ó鏂规硶鍙栨ǎ——婊胯冻瀹㈡埗涓嶅悓鐢ㄩ噺鐨勯渶姹�銆�